Studies of ischaemic and post-ischaemic paraesthesiae in normal subjects and in sciatica.
نویسنده
چکیده
The occurrence of paraesthesiae during occlusion of the circulation to a limb (ischaemic paraesthesiae) and after its restoration (post-ischaemic paraesthesiae) is well recognized. The ischaemic paraesthesiae consist of a soft, diffuse, tingling sensation felt at the periphery of the limb and lasting only a few minutes. The post-ischaemic paraesthesiae, which have been well demarcated by Merrington and Nathan (1949), are of four types: thermal, which are hot and cold sensations felt soon after restoration of the circulation to the limb; tingling, a soft, diffuse, vibrating feeling; pricking, composed of numerous, irregular, fine, discrete pricks; and pseudo-cramp, in which a sensation of movement in and tension of the muscle is experienced. The site of origin of these phenomena has been the subject of differing opinions. Weddell and Sinclair (1947) thought that, though the ischaemic paraesthesiae arose from the nerve trunk, the postischaemic paraesthesiae had their origin in the sensory end-organs. Lewis, Pickering, and Rothschild (1931), Bazett and McGlone (1932), and Zotterman (1933), on the other hand, have all considered that the post-ischaemic paraesthesiae arise in the nerve trunk. The careful studies of Merrington and Nathan (1949) have indicated that this latter view is correct. The primary purpose of the present work was to study the development of ischaemic and postischaemic paraesthesiae in the legs of patients suffering from sciatic pain due to a prolapsed intervertebral disc. Previous studies of ischaemic and post-ischaemic paraesthesiae have been concerned with the upper limb. It was, therefore, necessary first to study the development of these phenomena in the lower limbs of normal subjects to establish norms.
منابع مشابه
Ischaemic and postischaemic paraesthesiae in motor neurone disease.
In a recent study of ischaemic and post-ischaemic paraesthesiae in the upper limb (Poole, 1956a) it was noted that the responses in subjects with advanced motor neurone disease differed from those in normal subjects. This observation seemed relevant to the study both of motor neurone disease itself, and of factors which determine the production of paraesthesiae in normal and other diseased stat...
متن کاملIschaemic and post-ischaemic paraesthesiae; normal responses in the upper limb with special reference to the effect of age.
Paraesthesiae consequent on peripheral nerve compression or general limb ischaemia have long attracted interest, and many features suggest their possible value in the study of peripheral nerve disorders. However, it is not certain if they are an essential feature of normal nervous function or if any significance can be attached to their absence. To clarify this and to determine features suitabl...
متن کاملIschaemic and postischaemic paraesthesiae in polyneuritis.
Paraesthesiae consequent on peripheral nerve compression or general limb ischaemia have attracted interest for over a century (Bastien and Vulpian, 1855), but their value in the study of nervous disease remains little explored. In a recent study (Poole, 1956) the paraesthesiae provoked in normal subjects by a standard ischaemic test were investigated in order to provide a background against whi...
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Objective(s): Reperfusion of ischaemic myocardium results in reduced nitric oxide (NO) biosynthesis by endothelial nitric oxide synthase (eNOS) leading to endothelial dysfunction and subsequent tissue damage. Impaired NO biosynthesis may be partly due to increased levels of asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of eNOS. As dimethylarginine dimet...
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 15 4 شماره
صفحات -
تاریخ انتشار 1952